A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_URI::$config is deprecated
Filename: core/URI.php
Line Number: 101
Backtrace:
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Router::$uri is deprecated
Filename: core/Router.php
Line Number: 127
Backtrace:
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: Cannot modify header information - headers already sent by (output started at /home1/ab8102/public_html/edjcode/system/core/Exceptions.php:271)
Filename: core/Security.php
Line Number: 274
Backtrace:
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$benchmark is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$hooks is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$config is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$log is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$utf8 is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$uri is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$exceptions is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$router is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$output is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$security is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$input is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$lang is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$load is deprecated
Filename: core/Controller.php
Line Number: 78
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 129
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 280
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 151
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 208
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 297
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 335
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 282
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 289
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 304
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 314
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 315
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 316
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 317
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 375
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$db is deprecated
Filename: core/Loader.php
Line Number: 396
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated
Filename: database/DB_driver.php
Line Number: 371
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 110
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$session is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Javascript::$CI is deprecated
Filename: libraries/Javascript.php
Line Number: 81
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Jquery::$CI is deprecated
Filename: Javascript/Jquery.php
Line Number: 110
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: strpos(): Passing null to parameter #1 ($haystack) of type string is deprecated
Filename: libraries/Javascript.php
Line Number: 657
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$jquery is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Javascript::$js is deprecated
Filename: libraries/Javascript.php
Line Number: 86
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$javascript is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 10
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$mode is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 13
Function: model
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$Image_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 14
Function: model
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$benchmark is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$hooks is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$config is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$log is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$utf8 is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$uri is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$exceptions is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$router is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$output is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$security is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$input is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$lang is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$load is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$db is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$session is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$jquery is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$javascript is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$mode is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 154
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
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EDJ
,
Volume 1 No 1
156
Noura M. Kamal, Hend M. Salem And Heba M. Dahmoush ,
ABSTRACT
Background: Salivary Gland Cancers Are A Group Of Neoplasms Having Biological, Histological And Clinical Diversity. This Diversity Represents A Challenge For Diagnosis, Classification And Management Of Salivary Gland Cancers. We Believe That The Present Study Is The First To Compare And Correlate The Immunohistochemical Expression Of EpCAM In Different Grades Of Mucoepidermoid Carcinoma (MEC) And Solid Variant Of Adenoid Cystic Carcinoma (solid AdCC) In Comparison With The Normal Salivary Glands, To Ascertain The Possible Diagnostic And Prognostic Significance As Well As, Propose EpCAM Targeted Therapy As A Possible Treatment Approach For Patients With Salivary Gland Tumors.
Materials and Methods: 60 Specimens (12 Normal Salivary Gland Tissue, 36 MEC And 12 Solid AdCC) Were Collected And EpCAM Membranous Expression Was Evaluated By Immunohistochemistry. The Total Immunoscore (TIS) Was Evaluated, Which Represented The Product Of The Proportion Score And The Intensity Score. The Term ?EpCAM Overexpression? Was Given For Tissues Showing A Total Immunoscore >4.
Results: A Highly Significant Difference Was Observed Between TIS Percent Values In Control, Different Grades Of MEC And Solid AdCC (p< 0.001). High Grade MEC (HG-MEC) And Solid AdCC Were Found To Be The Highest EpCAM Expressors. Although, Lack Of EpCAM Expression Was Detected In Two Cases Of HG-MEC And One Case Of Solid AdCC.
Conclusion: EpCAM Was Frequently Detected In MEC And Solid AdCC Making These Tumours Potential Targets For Anti-EpCAM Therapies. The Diffuse Membranous Expression In HG-MEC Could Be Of Diagnostic Value In Relation To The Patchy Expression Observed In Both Low Grade And Intermediate Grade MEC.
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